02580nas a2200253   4500000000100000008004100001260005400042653001700096653001300113653002400126653001700150653001600167100001300183700001300196700001800209700001600227700001300243700001400256700001400270245011900284856016200403520173600565022002502301       2020                            d  bAmerican Society of Tropical Medicine and Hygiene10aParasitology10aVirology10aInfectious Diseases10aSurveillance10aElimination1 aRamzy RM1 aRabiee A1 aAbd Elaziz KM1 aCampbell CH1 aKittur N1 aColley DG1 aHaggag AA00aTest, Treat, Track, Test, and Treat Active Surveillance toward Elimination of Schistosomiasis: A Feasibility Study  uhttp://www.ajtmh.org/docserver/fulltext/10.4269/ajtmh.20-0156/tpmd200156.pdf?expires=1595247043&id=id&accname=guest&checksum=EC943D9BCA623FBC4CD60408DAC6ED383 aWe assessed the feasibility of using a test, treat, track, test, and treat (5T) active surveillance strategy to
identify and treat individuals with schistosomiasis in three very low-prevalence villages in Kafr El Sheikh Governorate, Egypt. Primary index cases (PICs) were identified using the point-of-care circulating cathodic antigen (POC-CCA) assay in schools, in rural health units (retesting individuals with positive Kato–Katz examinations over the previous 6 months), and at potential water transmission sites identified by PICs and field observations. Primary cases identified potential second generation cases—people with whom they shared water activities—who were then tracked, tested, and treated if infected. Those sharing water activities with second-generation cases were also tested. The yield of PICs from the three venues were 128 of 3,576 schoolchildren (3.6%), 42 of 696 in rural health units (6.0%), and 83 of 1,156 at water contact sites (7.2%). There were 118 second- and 19 third-generation cases identified. Persons testing positive were treated with praziquantel. Of 388 persons treated, 368 (94.8%) had posttreatment POC-CCA tests 3–4 weeks after treatment, and 81.8% (301) became negative. The 67 persons remaining positive had negative results after a second treatment. Therefore, all those found positive, treated, and followed up were negative following one or two treatments. Analysis of efforts as expressed in person-hours indicates that 4,459 person-hours were required for these 5T activities, with nearly 65% of that time spent carrying out interviews, treatments, and evaluations following treatment. The 5T strategy appears feasible and acceptable as programs move toward elimination.  a0002-9637, 1476-1645