01061nas a2200133   4500000000100000008004100001260001200042653001700054100001800071245008400089856006100173520067900234022001400913       2020                            d  c08/202010aPraziquantel1 aSpangenberg T00aAlternatives to Praziquantel for the Prevention and Control of Schistosomiasis.  uhttps://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.0c005423 a<p>Schistosomiasis, a neglected tropical disease provoked by infection with parasitic blood flukes of the genus , affects almost 240 million people worldwide, and more than 700 million people live in endemic areas. However, 40 years after the approval of praziquantel as an anthelmintic drug, the pipeline is nearly empty, and no other therapeutic alternative has reached the market. In its roadmap to "eliminate Schistosomiasis as a public health problem by 2030", the World Health Organization calls for the development of new therapeutic interventions. A viewpoint on the learnings from praziquantel research as well as shaping the next generation of drugs is shared.</p>  a2373-8227