01677nas a2200265   4500000000100000008004100001260005300042653002700095653001700122653002400139653002500163653000900188100001300197700001700210700001500227700001300242700001300255700001200268700001200280245006100292300001400353490000700367520101200374022002501386       2020                            d  bCenters for Disease Control and Prevention (CDC)10aMicrobiology (medical)10aEpidemiology10aInfectious Diseases10aTreatment strategies10aYaws1 aHolmes A1 aTildesley MJ1 aSolomon AW1 aMabey DC1 aSokana O1 aMarks M1 aDyson L00aModeling Treatment Strategies to Inform Yaws Eradication  a2685-26930 v263 aYaws is a neglected tropical disease targeted for eradication by 2030. To achieve eradication, finding and treating asymptomatic infections as well as clinical cases is crucial. The proposed plan, the Morges strategy, involves rounds of total community treatment (i.e., treating the whole population) and total targeted treatment (TTT) (i.e., treating clinical cases and contacts). However, modeling and empirical work suggests asymptomatic infections often are not found in the same households as clinical cases, reducing the utility of household-based contact tracing for a TTT strategy. We use a model fitted to data from the Solomon Islands to predict the likelihood of elimination of transmission under different intervention schemes and levels of systematic nontreatment resulting from the intervention. Our results indicate that implementing additional treatment rounds through total community treatment is more effective than conducting additional rounds of treatment of at-risk persons through TTT.  a1080-6040, 1080-6059