02082nas a2200193 4500000000100000008004100001260001200042653000900054653002000063653003400083653001600117100001600133700001700149245010600166856007900272490000700351520151600358022001401874 2020 d c10/202010aLAMP10adiagnostic test10aneglected parasitic infection10asensitivity1 aAvendaño C1 aPatarroyo MA00aLoop-Mediated Isothermal Amplification as Point-of-Care Diagnosis for Neglected Parasitic Infections. uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662217/pdf/ijms-21-07981.pdf0 v213 a

The World Health Organisation (WHO) has placed twenty diseases into a group known as neglected tropical diseases (NTDs), twelve of them being parasitic diseases: Chagas' disease, cysticercosis/taeniasis, echinococcosis, food-borne trematodiasis, human African trypanosomiasis (sleeping sickness), leishmaniasis, lymphatic filariasis, onchocerciasis (river blindness), schistosomiasis, soil-transmitted helminthiasis (ascariasis, hookworm, trichuriasis), guinea-worm and scabies. Such diseases affect millions of people in developing countries where one of the main problems concerning the control of these diseases is diagnosis-based due to the most affected areas usually being far from laboratories having suitable infrastructure and/or being equipped with sophisticated equipment. Advances have been made during the last two decades regarding standardising and introducing techniques enabling diagnoses to be made in remote places, i.e., the loop-mediated isothermal amplification (LAMP) technique. This technique's advantages include being able to perform it using simple equipment, diagnosis made directly in the field, low cost of each test and the technique's high specificity. Using this technique could thus contribute toward neglected parasite infection (NPI) control and eradication programmes. This review describes the advances made to date regarding LAMP tests, as it has been found that even though several studies have been conducted concerning most NPI, information is scarce for others.

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