01372nas a2200181 4500000000100000008004100001260003400042653005700076653001700133653002400150653002100174100001400195700001400209700001400223245006500237520086300302022002501165 2020 d bOxford University Press (OUP)10aPublic Health, Environmental and Occupational Health10aParasitology10aInfectious Diseases10aGeneral Medicine1 aAddiss DG1 aKienast Y1 aLavery JV00aEthical dimensions of neglected tropical disease programming3 aAbstract The global movement to control and eliminate neglected tropical diseases (NTDs) is grounded in an ethic of social justice, solidarity and health equity. NTD programmes deliver significant health benefits in socially complex environments characterized by poverty and economic disparity. We used two ethics frameworks—principlism and Upshur's public health framework—to examine ethical challenges faced by NTD programmes. They include management of serious adverse reactions associated with preventive chemotherapy, centralization of decision-making, ‘opt-out’ policies for school-based deworming, incomplete evidence for ‘pro-poor’ impact and persistent inequities in global partnerships. NTD programmes must actively address ethical challenges while pursuing global health goals. a0035-9203, 1878-3503