00519nas a2200181   4500000000100000008004100001260001600042653002100058653002900079100001200108700001500120700001200135700001800147700001800165245006500183856007500248022001400323       2021                            d  bElsevier BV10aGeneral Medicine10aClinical Trials as Topic1 aHowie A1 aTaljaard M1 aMoon PM1 aNightingale N1 aZwarenstein M00aAddressing the disconnect between trial intention and design  uhttps://www.thelancet.com/action/showPdf?pii=S2214-109X%2820%2930543-X  a2214-109X