01958nas a2200313   4500000000100000008004100001260005300042653002700095653001700122653002400139100001600163700001300179700001300192700001300205700001600218700001300234700001600247700001400263700001500277700001400292700001400306700001200320245006400332856006000396300001400456490000700470520114200477022002501619       2021                            d  bCenters for Disease Control and Prevention (CDC)10aMicrobiology (medical)10aEpidemiology10aInfectious Diseases1 aTimothy JWS1 aBeale MA1 aRogers E1 aZaizay Z1 aHalliday KE1 aMulbah T1 aGiddings RK1 aWalker SL1 aThomson NR1 aKollie KK1 aPullan RL1 aMarks M00aEpidemiologic and Genomic Reidentification of Yaws, Liberia  uhttps://wwwnc.cdc.gov/eid/article/27/4/pdfs/20-4442.pdf  a1123-11320 v273 aWe confirmed endemicity and autochthonous transmission of yaws in Liberia after a population-based, community-led burden estimation (56,825 participants). Serologically confirmed yaws was rare and focal at population level (24 cases; 2.6 [95% CI 1.4–3.9] cases/10,000 population) with similar clinical epidemiology to other endemic countries in West Africa. Unsupervised classification of spatially referenced case finding data indicated that yaws was more likely to occur in hard-to-reach communities; healthcare-seeking was low among communities, and clinical awareness of yaws was low among healthcare workers. We recovered whole bacterial genomes from 12 cases and describe a monophyletic clade of Treponema pallidum subspecies pertenue, phylogenetically distinct from known TPE lineages, including those affecting neighboring nonhuman primate populations (Taï Forest, Côte d’Ivoire). Yaws is endemic in Liberia but exhibits low focal population prevalence with evidence of a historical genetic bottleneck and subsequent local expansion. Reporting gaps appear attributable to challenging epidemiology and low disease awareness.  a1080-6040, 1080-6059