02375nas a2200193 4500000000100000008004100001260002500042653004600067653002300113653001500136100001500151700001400166700001500180700001600195245010000211856006600311520177900377022002502156 2022 d bMary Ann Liebert Inc10aCritical Care and Intensive Care Medicine10aEmergency Medicine10aLymphedema1 aTorgbenu E1 aLuckett T1 aBuhagiar M1 aPhillips JL00aGuidelines relevant to diagnosis, assessment and management of lymphoedema: a systematic review uhttps://www.liebertpub.com/doi/reader/10.1089/wound.2021.01493 a

Significance: Lymphoedema is a common, distressing and debilitating condition with various aetiologies. Effective diagnosis, assessment and management rely on evidence-based clinical practice guidelines (“guidelines”). This study aims to describe and compare international guidelines on lymphoedema diagnosis, assessment and management. Recent Advances: The review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, and registered on the International Prospective Register of Systematic Reviews (PROSPERO). Systematic searches of electronic literature databases and the web were completed in December 2020 for lymphoedema guidelines published in English since 2000. Quality was assessed using the AGREE-II reporting checklist. Synthesis took a narrative approach to compare guideline recommendations and associated levels of evidence. Critical issues: This systematic review of 1564 articles and 159 web pages yielded 14 guidelines. All guidelines were from high-income countries. Ten focused exclusively on lymphoedema, and four on cancer. Most (n=13) guidelines recommended an integrated medical, psychological assessment and physical examination, with a limb volume measurement of >10% in the affected limb compared, confirming a lymphoedema diagnosis. Recommended management involved Complex Decongestive Therapy (CDT) followed by self-management using skincare, self-lymphatic drainage massage, exercise and compression. Future directions: The underlying aetiology of lymphoedema appeared to make little difference to guideline recommendations regarding care. High-quality guidelines are available to guide lymphoedema care. However, their suitability for low resource settings is unclear.

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