01911nas a2200277   4500000000100000008004100001260001200042653002300054653002000077653001500097653002400112653001200136100001700148700001700165700001300182700002000195700001700215700002600232700002700258700002700285700002400312245013800336856009100474520105400565022001401619       2022                            d  c03/202210aDominican Republic10aM. lepromatosis10atratamento10alepromatous leprosy10aleprosy1 aFernández J1 aPou-Soarez V1 aArenas R1 aJuárez-Duran E1 aLuna-Rojas S1 aXicohtencatl-Cortes J1 aMartínez-Chavarría L1 aMartínez-Hernández F1 aHernández-Castro R00aMycobacterium leprae and Mycobacterium lepromatosis infection. A report of six multibacillary cases of leprosy in Dominican Republic.  uhttps://www.jstage.jst.go.jp/article/yoken/advpub/0/advpub_JJID.2021.709/_pdf/-char/en3 a<p>The causative agents of leprosy are Mycobacterium leprae and Mycobacterium lepromatosis. M. lepromatosis was found in 2008 to cause diffuse lepromatous leprosy in Mexican patients. The objective of this work was to identify M. leprae and M. lepromatosis in paraffin-embedded skin samples from Caribbean leprosy patients. A total of 6 skin samples were obtained from the Dominican Republic. All cases presented the multibacillary form; 5 cases were nodular lepromatous leprosy, and 1 case was borderline lepromatous leprosy. All patients received multidrug therapy. Molecular identification was achieved using the M. leprae-specific repetitive element (RLEP) for M. leprae and the hemN gene for M. lepromatosis. Mycobacterium leprae was identified in two lepromatous leprosy cases and 1 borderline lepromatous leprosy case; M. lepromatosis was found in 1 nodular lepromatous leprosy case. Both Mycobacterium species were present in two nodular lepromatous leprosy cases. This is the first report of M. lepromatosis in the Dominican Republic.</p>
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