02476nas a2200493   4500000000100000008004100001260001200042653001400054653003200068653002100100653001400121653001500135100001200150700001300162700001700175700001400192700001200206700001000218700001500228700001300243700001500256700001400271700001200285700001400297700001400311700001400325700001700339700001600356700001400372700001400386700001300400700001300413700001400426700001500440700001400455700001000469700001400479700001500493245010200508856006700610490000700677520128400684022001401968       2022                            d  c05/202210aAntivenom10aclinical practice guideline10aHealth Education10asnakebite10aValidation1 aRocha G1 aFarias A1 aAlcântara J1 aMachado V1 aMurta F1 aVal F1 aCristino J1 aSantos A1 aFerreira M1 aMarques L1 aRocha Y1 aSachett A1 aAlmeida M1 aAlencar A1 aBrasileiro L1 aCarvalho É1 aBisneto P1 aLacerda M1 aTupetz A1 aStaton C1 aVissoci J1 aTeixeira E1 aGerardo C1 aWen F1 aSachett J1 aMonteiro W00aValidation of a Culturally Relevant Snakebite Envenomation Clinical Practice Guideline in Brazil.  uhttps://www.mdpi.com/2072-6651/14/6/376/pdf?version=16538111100 v143 a<p>Snakebite envenoming (SBE) is a neglected tropical disease with significant global morbidity and mortality. Even when antivenom is available in low-resource areas, health workers do not receive adequate training to manage SBEs. This study aims to develop and validate a clinical practice guideline (CPG) for SBE management across Brazil. A panel of expert judges with academic and/or technical expertise in SBE management performed content validation. The content validity index (CVI) score was 90% for CPG objectives, 89% for structure and presentation and 92% for relevance and classified the CPG as valid. A semantic validation was performed by analyzing focus group discussions with doctors and nurses from three municipalities of the Brazilian Amazon, after a 5-day meeting during which the CPG was presented. Two central themes emerged: knowledge acquired during the meeting and recommendations for improving the CPG. Based on these results, the CPG was revised into a final version. This study presents the successful development and validation process of a CPG for SBE management, which is targeted to a specific low-resource, high-burden setting. This development and validation process can be adapted to other settings and/or other neglected tropical diseases.</p>
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