01999nas a2200349 4500000000100000008004100001260001400042653004300056653002100099653002600120100002400146700002400170700001300194700001300207700001400220700001800234700001100252700001400263700002100277700002200298700001200320700001800332700001300350700002100363700001600384245008000400856007200480300000800552490000700560520106800567022001401635 2022 d bIMR Press10aCardiology and Cardiovascular Medicine10aGeneral Medicine10athe NET-Heart Project1 aMiranda-Arboleda AF1 aGonzalez-Barrera LG1 aLiblik K1 aFarina J1 aZaidel EJ1 aSaldarriaga C1 aZhou Z1 aAl-Rawi R1 aLópez-López JP1 aJuarez-Lloclla JP1 aGupta S1 aPrabhakaran D1 aKumar RK1 aSosa-Liprandi Á1 aBaranchuk A00aNeglected Tropical Diseases and Sudden Cardiac Death: The NET-Heart Project uhttps://www.imrpress.com/journal/RCM/23/7/10.31083/j.rcm2307254/pdf a2540 v233 a

Sudden cardiac death (SCD) is responsible for approximately 6% of global mortality and 25% of cardiovascular (CV) deaths. SCD has been traditionally linked to coronary artery disease, valvular heart disease, cardiomyopathies, and genetic arrhythmia disorders. However, advancements in care for these diseases have not translated to a proportional reduction in SCD. This suggests an important role of underrecognized contributing pathologies. Neglected tropical diseases (NTDs) are a group of illnesses prevalent in tropical and sub-tropical regions which have been understudied partially due to their high prevalence in marginalized populations. The relationship between SCD and Chagas disease has been well-established, though emerging literature suggests that other NTDs with CV involvement may lead to fatal arrhythmias. Additionally, specific therapies for a subset of NTDs put patients at increased risk of malignant arrhythmias and other cardiac complications. This review aims to summarize the association between a group of selected NTDs and SCD.

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