01952nas a2200241   4500000000100000008004100001260001600042653002400058653001700082653001900099653003100118100001400149700001200163700001400175700001500189700001500204700001600219700001300235245007500248300001100323520136200334022001401696       2022                            d  bElsevier BV10aInfectious Diseases10aParasitology10aInsect Science10aVeterinary (miscellaneous)1 aSantos FA1 aCruz GS1 aVieira FA1 aQueiroz BR1 aFreitas CD1 aMesquita FP1 aSouza PF00aSystematic Review of Antiprotozoal Potential of Antimicrobial Peptides  a1066753 a<p>Protozoa is a group of microorganisms that cause neglected tropical diseases, such as malaria, Chagas disease, and Leishmaniasis. Due to the growing demand for new therapeutic agents, antimicrobial peptides (AMPs) have gained attention for antiprotozoal action. A systematic literature review described the current scenario of plant and animal AMPs with action antiprotozoal. The terms "antimicrobial peptides", "plant", and “animal” combined with the names of the etiological agents were used in the search. Boolean and Operator were used to connect the terms. The search found 4,825 articles. However, 79 articles were excluded because they were duplicates, and 4,627 were excluded based on title and abstract. Therefore, 119 were evaluated and included here. Of these, the use of antimicrobial peptides of animal origin was predominant. Still, the works with plant peptides focused on the genus Leishmania. Only antimicrobial peptides of animal origin were described for the other genera of protozoa (<em>Toxoplasma</em>&nbsp;spp,&nbsp;<em>Trypanosoma</em>&nbsp;spp,&nbsp;<em>Plasmodium</em>&nbsp;spp). Antimicrobial peptides are an excellent option as a pharmacological tool to fight these infections due to their aggregation and extravasation of cellular content through the formation of pores in the cell membrane of these microorganisms.</p>
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