02363nas a2200241 4500000000100000008004100001260003400042653002400076653005700100653002100157653001700178100001300195700001500208700001200223700001400235700001200249700001500261700001100276245009100287856010400378520161400482022002502096 2022 d bOxford University Press (OUP)10aInfectious Diseases10aPublic Health, Environmental and Occupational Health10aGeneral Medicine10aParasitology1 aDeribe K1 aSultani HM1 aOkoyo C1 aOmondi WP1 aNgere I1 aNewport MJ1 aCano J00aGeostatistical modelling of the distribution, risk and burden of podoconiosis in Kenya uhttps://academic.oup.com/trstmh/advance-article-pdf/doi/10.1093/trstmh/trac092/45967087/trac092.pdf3 a

Background: Understanding and accurately predicting the environmental limits, population at risk and burden of podoconiosis are critical for delivering targeted and equitable prevention and treatment services, planning control and elimination programs and implementing tailored case finding and surveillance activities.

Methods: This is secondary analysis of a nationwide podoconiosis mapping survey in Kenya. We combined national representative prevalence survey data of podoconiosis with climate and environmental data, overlayed with population figures in a geostatistical modelling framework, to predict the environmental suitability, population living in at-risk areas and number of cases of podoconiosis in Kenya.

Results: In 2020, the number of people living with podoconiosis in Kenya was estimated to be 9344 (95% uncertainty interval 4222 to 17 962). The distribution of podoconiosis varies by geography and three regions (Eastern, Nyanza and Western) represent >90% of the absolute number of cases. High environmental suitability for podoconiosis was predicted in four regions of Kenya (Coastal, Eastern, Nyanza and Western). In total, 2.2 million people live in at-risk areas and 4.2% of the total landmass of Kenya is environmentally predisposed for podoconiosis.

Conclusions: The burden of podoconiosis is relatively low in Kenya and is mostly restricted to certain small geographical areas. Our results will help guide targeted prevention and treatment approaches through local planning, spatial targeting and tailored surveillance activities.

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