01951nas a2200409   4500000000100000008004100001260002300042653002100065100001800086700001700104700001400121700001300135700001400148700001400162700001200176700001400188700001600202700001300218700001700231700001400248700001400262700001600276700001200292700001600304700001400320700001700334700001500351700001400366700001300380700001500393700001500408245005500423856007000478490000600548520097300554022001401527       2022                            d  bFrontiers Media SA10aGeneral Medicine1 aFrallonardo L1 aDi Gennaro F1 aPanico GG1 aNovara R1 aPallara E1 aCotugno S1 aGuido G1 aDe Vita E1 aRicciardi A1 aTotaro V1 aCamporeale M1 aDe Iaco G1 aBavaro DF1 aLattanzio R1 aPatti G1 aBrindicci G1 aPapagni R1 aPellegrino C1 aSantoro CR1 aSegala FV1 aPutoto G1 aNicastri E1 aSaracino A00aOnchocerciasis: Current knowledge and future goals  uhttps://www.frontiersin.org/articles/10.3389/fitd.2022.986884/pdf0 v33 a<p>Human Onchocerciasis, caused by infection by the filarial nematode Onchocerca volvulus, is a neglected public health disease that affects millions of people in the endemic regions of sub-Saharan Africa and Latin America. It is also called river blindness because the Blackflies that transmit infection breeds in rapidly flowing fresh water streams and rivers. This review features state-of-the-art data on the parasite, its endobacteria Wolbachia, the prevalence of the infection and its geographical distribution, its diagnostics, the interaction between the parasite and its host, and the pathology of Onchocerciasis. By development and optimization of the control measures, transmission by the vector has been interrupted in foci of countries in the Americas (Colombia, Ecuador, Mexico, and Guatemala)and in Sudan, followed by Onchocerciasis eliminations. The current state and future perspectives for vector control and elimination strategy are described.</p>
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