02550nas a2200301   4500000000100000008004100001260002400042653002400066653002700090653001700117100001300134700001700147700001400164700001900178700001600197700001700213700001400230700002400244700001300268700001600281700001500297700001300312245014800325856008000473490000700553520166300560022002502223       2022                            d  bFapUNIFESP (SciELO)10aInfectious Diseases10aMicrobiology (medical)10aParasitology1 aSilva WT1 aOliveira LFF1 aXavier DM1 aFigueiredo PHS1 aLacerda ACR1 aMendonça VA1 aÁvila MR1 aFerreira Júnior CL1 aLima MMO1 aMediano MFF1 aRocha MODC1 aCosta HS00aHealth-Related Quality of Life Reported by Patients With Chagas Disease: A Systematic Review of Qualitative Evidence With GRADE Recommendations  uhttps://www.scielo.br/j/rsbmt/a/WhscK5tHkrfhDKkmhJ3SNkb/?format=pdf&lang=en0 v553 a<p>Patients with Chagas disease have reduced health-related quality of life (HRQoL). Hence, we aimed to identify the factors that mostly affected their HRQoL. This was a systematic review of qualitative studies. The Latin American and Caribbean Health Sciences Literature, Medical Literature Analysis and Retrieval System Online, Excerpta Medica Database, Web of Science, and SciVerse Scopus databases were searched for relevant studies without language or date restrictions. The search and data analysis were performed by independent reviewers; all qualitative studies that reported the factors that had an impact on the HRQoL of patients with Chagas disease were included. The risk of bias was assessed using the Critical Appraisal Skills Program Qualitative Study Checklist; confidence in the evidence was evaluated using the Grading of Recommendations Assessment, Development and Evaluation-Confidence in the Evidence from Reviews of Qualitative approach. Five studies were included in this review: four in Brazil and one in California, United States, with immigrants from Central and South America. The sample consisted of 207 patients with chronic Chagas disease. Stigma, physical limitations, work absenteeism, emotional or mental aspects, fear of treatment, and fear of the future had the strongest impact on the HRQoL. All items showed moderate confidence except for fear of treatment (low confidence). The physical, emotional, mental, and cultural aspects affected the HRQoL of patients with chronic Chagas disease. Identification of these factors is important in the development of strategies aimed at improving the HRQoL of this population.</p>
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