01860nas a2200265   4500000000100000008004100001260001600042653002100058653004000079653001500119653001500134100001000149700001300159700001100172700001300183700001200196700001200208700001300220700001600233700001400249700001500263245012900278520117300407022001401580       2023                            d  bElsevier BV10aGeneral Medicine10aPost kala-azar dermal leishmaniasis10aManagement10aPrevention1 aPal B1 aKumari S1 aKaur M1 aWadhwa P1 aMurti K1 aKumar R1 aPandey K1 aSiddiqui NA1 aDhingra S1 aPadmakar S00aBarriers to the effective management and prevention of post kala-azar dermal leishmaniasis (PKDL) in the Indian subcontinent3 a<p>Post kala-azar&nbsp;dermal leishmaniasis&nbsp;(PKDL) is a&nbsp;skin disease&nbsp;that usually occurs among individuals with a past history of visceral leishmaniasis (VL). PKDL cases act as a reservoir of&nbsp;parasites&nbsp;and may play a significant role in&nbsp;disease transmission. Hence,&nbsp;prompt&nbsp;detection and complete&nbsp;treatment&nbsp;of PKDL cases are crucial for the control and elimination of VL. The purpose of this review was to highlight the barriers to effective control and prevention of VL/PKDL as well as potential solutions in India. Main obstacles are lack of knowledge about the disease and its vector, poor treatment-seeking behaviours, ineffective vector control measures, lack of confirmatory diagnostics in endemic areas, limited drug choices,&nbsp;treatment&nbsp;noncompliance among&nbsp;patients, drug resistance, and a lack of an adequate number of trained personnel in the&nbsp;health system. Therefore, in order to control and successfully eliminate VL in the Indian subcontinent, early detection of PKDL cases, improved diagnosis and treatment, raising awareness, and effective vector control mechanisms are necessary.</p>
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