01468nas a2200289   4500000000100000008004100001260003700042653002400079653005700103100001100160700001500171700001600186700001600202700001200218700001800230700001600248700001700264700001500281700001500296700001600311245015000327856009900477300001300576490000700589520056800596022001401164       2023                            d  bPublic Library of Science (PLoS)10aInfectious Diseases10aPublic Health, Environmental and Occupational Health1 aMuhi S1 aOsowicki J1 aO’Brien D1 aJohnson PDR1 aPidot S1 aDoerflinger M1 aMarshall JL1 aPellegrini M1 aMcCarthy J1 aStinear TP1 aConverse PJ00aA human model of Buruli ulcer: The case for controlled human infection and considerations for selecting a Mycobacterium ulcerans challenge strain  uhttps://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0011394&type=printable  ae00113940 v173 a<p>Critical knowledge gaps regarding infection with Mycobacterium ulcerans, the cause of Buruli ulcer (BU), have impeded development of new therapeutic approaches and vaccines for prevention of this neglected tropical disease. Here, we review the current understanding of host–pathogen interactions and correlates of immune protection to explore the case for establishing a controlled human infection model of M. ulcerans infection. We also summarise the overarching safety considerations and present a rationale for selecting a suitable challenge strain.</p>
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