01418nas a2200205   4500000000100000008004100001260001600042653002400058653001700082100001100099700001200110700001600122700001500138700001700153245008500170856007000255300000900325520086400334022001401198       2023                            d  bElsevier BV10aInfectious Diseases10aParasitology1 aLim RM1 aArme TM1 aPedersen AB1 aWebster JP1 aLamberton PH00aDefining schistosomiasis hotspots based on literature and shareholder interviews  uhttps://www.cell.com/action/showPdf?pii=S1471-4922%2823%2900227-1  a1-183 a<p>The World Health Organization (WHO) recently proposed a new operational definition which designates communities with ≥10% prevalence of&nbsp;<em>Schistosoma</em>&nbsp;spp. infection as a persistent hotspot, when, after at least two rounds of high-coverage annual preventive chemotherapy, there is a lack of appropriate reduction. However, inconsistencies and challenges from both biological and operational perspectives remain, making the prescriptive use of this definition difficult. Here, we present a comprehensive analysis of the use of the term ‘hotspot’ across schistosomiasis research over time, including both literature searches and opinions from a range of stakeholders, to assess the utility and generalisability of the new WHO definition of a persistent hotspot. Importantly, we propose an updated definition based on our analyses.</p>
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