02294nas a2200289   4500000000100000008004100001260001200042653001600054653001300070653001200083653001000095100001400105700001500119700001400134700001500148700001400163700001500177700001000192700001400202700001400216700001200230245004000242856015300282300000900435520154600444022001401990       2023                            d  c10/202310aFeasibility10aHookworm10aVaccine10aValue1 aPuchner K1 aBottazzi M1 aPeriago V1 aGrobusch M1 aMaizels R1 aMcCarthy J1 aLee B1 aGaspari E1 aDiemert D1 aHotez P00aVaccine value profile for Hookworm.  uhttps://www.sciencedirect.com/science/article/pii/S0264410X23005406/pdfft?md5=0705e9ff79bbf78623c22c5bee9f860a&pid=1-s2.0-S0264410X23005406-main.pdf  a1-173 a<p>Hookworm, a parasitic infection, retains a considerable burden of disease, affecting the most underprivileged segments of the general population in endemic countries and remains one of the leading causes of mild to severe anemia in Low and Middle Income Countries (LMICs), particularly in pregnancy and children under 5. Despite repeated large scale Preventive Chemotherapy (PC) interventions since more than 3 decades, there is broad consensus among scholars that elimination targets set in the newly launched NTD roadmap will require additional tools and interventions. Development of a vaccine could constitute a promising expansion of the existing arsenal against hookworm. Therefore, we have evaluated the biological and implementation feasibility of the vaccine development as well as the added value of such a novel tool. Based on pipeline landscaping and the current knowledge on key biological aspects of the pathogen and its interactions with the host, we found biological feasibility of development of a hookworm vaccine to be moderate. Also, our analysis on manufacturing and regulatory issues as well as potential uptake yielded moderate implementation feasibility. Modelling studies suggest a that introduction of a vaccine in parallel with ongoing integrated interventions (PC, WASH, shoe campaigns), could substantially reduce burden of disease in a cost - saving mode. Finally a set of actions are recommended that might impact positively the likelihood of timely development and introduction of a hookworm vaccine.</p>
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