02423nas a2200313   4500000000100000008004100001260002400042653002400066653002700090653001700117653001900134653002000153653002400173653001600197100001500213700001600228700001700244700001500261700001600276700001600292700001400308700001500322245007400337856008000411300000800491490000700499520157800506022002502084       2023                            d  bFapUNIFESP (SciELO)10aInfectious Diseases10aMicrobiology (medical)10aParasitology10aChagas disease10aQuality of Life10a Neglected diseases10aBlood Donor1 aBaldoni NR1 aQuintino ND1 aOliveira CDL1 aSilva JLPD1 aFerreira AM1 aRibeiro ALP1 aSabino EC1 aCardoso CS00aChagas disease and perceived quality of life: a cross-sectional study  uhttps://www.scielo.br/j/rsbmt/a/g7nnT3KYJRn5SrnCkrtfcff/?format=pdf&lang=en  a1-80 v563 a<p><strong>Background:&nbsp;</strong>Chagas disease (ChD) is a neglected tropical disease that is caused by the protozoan parasite&nbsp;<em>Trypanosoma cruzi</em>&nbsp;and can negatively impact quality of life (QoL). This study aimed to assess and compare QoL between individuals with and without ChD.</p>

<p><strong>Methods:&nbsp;</strong>This cross-sectional study was performed within a concurrent cohort study (REDS). The participants were derived from two blood donation centers: São Paulo capital and Montes Claros, Minas Gerais, Brazil. Participants with ChD were identified in blood donations by serological diagnosis between 2008 and 2010, and those without ChD were donors with negative serology identified during the same period. QoL was assessed using the World Health Organization Quality of Life-BREF questionnaire. Logistic regression was used to compare sociodemographic and clinical characteristics between the groups, and mean, standard deviation, and beta regression were used to compare QoL.</p>

<p><strong>Results:&nbsp;</strong>In total, 611 individuals participated in the study (328 with ChD and 283 without ChD). Participants with ChD had lower QoL in the physical (p=0.02) and psychological (p&lt;0.01) domains than did individuals without CD.</p>

<p><strong>Conclusions:&nbsp;</strong>Individuals with ChD had worse QoL perceptions. These results provide a comprehensive understanding of the impact of ChD on individuals' QoL, while also highlighting potential opportunities for improving the care and treatment of those affected.</p>
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