The emergence of artificial intelligence (AI) in drug discovery represents a transformative development in addressing neglected diseases, particularly in the context of the developing world. Neglected diseases, often overlooked by traditional pharmaceutical research due to limited commercial profitability, pose significant public health challenges in low- and middle-income countries. AI-powered drug discovery offers a promising solution by accelerating the identification of potential drug candidates, optimising the drug development process, and reducing the time and cost associated with bringing new treatments to market. However, while AI shows promise, many of its applications are still in their early stages and require human validation to ensure the accuracy and reliability of predictions. Additionally, AI models are limited by the availability of high-quality data, which is often sparse in regions where neglected diseases are most prevalent. This viewpoint explores the application of AI in drug discovery for neglected diseases, examining its current impact, related ethical considerations, and the broader implications for public health in the developing world. It also highlights the challenges and opportunities presented by AI in this context, emphasising the need for ongoing research, ethical oversight, and collaboration between public health stakeholders to fully realise its potential in transforming global health outcomes.
BT - Journal of global health C1 -https://www.ncbi.nlm.nih.gov/pubmed/39791403
DA - 01/2025 DO - 10.7189/jogh.15.03002 J2 - J Glob Health LA - ENG M3 - Article N2 -The emergence of artificial intelligence (AI) in drug discovery represents a transformative development in addressing neglected diseases, particularly in the context of the developing world. Neglected diseases, often overlooked by traditional pharmaceutical research due to limited commercial profitability, pose significant public health challenges in low- and middle-income countries. AI-powered drug discovery offers a promising solution by accelerating the identification of potential drug candidates, optimising the drug development process, and reducing the time and cost associated with bringing new treatments to market. However, while AI shows promise, many of its applications are still in their early stages and require human validation to ensure the accuracy and reliability of predictions. Additionally, AI models are limited by the availability of high-quality data, which is often sparse in regions where neglected diseases are most prevalent. This viewpoint explores the application of AI in drug discovery for neglected diseases, examining its current impact, related ethical considerations, and the broader implications for public health in the developing world. It also highlights the challenges and opportunities presented by AI in this context, emphasising the need for ongoing research, ethical oversight, and collaboration between public health stakeholders to fully realise its potential in transforming global health outcomes.
PY - 2025 SP - 1 EP - 10 T2 - Journal of global health TI - AI-powered drug discovery for neglected diseases: accelerating public health solutions in the developing world. UR - https://pmc.ncbi.nlm.nih.gov/articles/PMC11719738/pdf/jogh-15-03002.pdf VL - 15 SN - 2047-2986 ER -