TY - JOUR
KW - Chronic schistosomiasis
KW - Immunochromatography
KW - Point-of-care diagnostics
KW - schistosomiasis screening
KW - sub-Saharan migrants
AU - Hegazy AHA
AU - Pérez-Quílez  O
AU - López-Muñoz I
AU - Chamorro A
AU -  Abad E
AU - San José A
AU -  Valera J
AU - Valerio L
AU - Soldevila L
AU - Gorriz E
AU - Herena D
AU - Fernández-Pedregal E
AU - Llibre JM
AU - Fernández-Rivas G
AU - Joan Cardona P
AU - Vallès X
AU -  Roure S
AB - <p><strong>Background</strong></p>

<p>Imported schistosomiasis is underdiagnosed among long-term migrants in non-endemic countries. Reference standard tests are lacking for the diagnosis of chronic schistosomiasis.</p>

<p><strong>Methods</strong></p>

<p>This study evaluated the sensitivity and specificity of a new immunochromatography (ICT) test using serum (s) or point-of-care finger-prick (FP) whole blood against standard serological tests in long-term migrants from sub-Saharan Africa.</p>

<p><strong>Results</strong></p>

<p>A total of 202 individuals were screened, with a mean age of 42.7 years. Of these, 75.7% were male, and 42.6% were from Senegal. Test positivity rates were 15.8% for ELISA, 24.3% for ICT-p, 46.5% for ICT-b (s), and 28.7% for ICT-b (FP). All tests showed good agreement with a clinical score but with heterogeneous agreement between them. Our results indicates a higher sensitivity for ICT-b (s). Positive responses after treatment suggest good specificity for all tests.</p>

<p><strong>Conclusions</strong></p>

<p>ICT-b (s) shows a higher sensitivity than the other standard tests. An ICT-b (FP) strategy could be used as a first-step point-of-care screening tool for probable chronic schistosomiasis.</p>

BT - Open Forum Infectious Diseases
IS - 7
LA - eng
M3 - Research Article
N2 - <p><strong>Background</strong></p>

<p>Imported schistosomiasis is underdiagnosed among long-term migrants in non-endemic countries. Reference standard tests are lacking for the diagnosis of chronic schistosomiasis.</p>

<p><strong>Methods</strong></p>

<p>This study evaluated the sensitivity and specificity of a new immunochromatography (ICT) test using serum (s) or point-of-care finger-prick (FP) whole blood against standard serological tests in long-term migrants from sub-Saharan Africa.</p>

<p><strong>Results</strong></p>

<p>A total of 202 individuals were screened, with a mean age of 42.7 years. Of these, 75.7% were male, and 42.6% were from Senegal. Test positivity rates were 15.8% for ELISA, 24.3% for ICT-p, 46.5% for ICT-b (s), and 28.7% for ICT-b (FP). All tests showed good agreement with a clinical score but with heterogeneous agreement between them. Our results indicates a higher sensitivity for ICT-b (s). Positive responses after treatment suggest good specificity for all tests.</p>

<p><strong>Conclusions</strong></p>

<p>ICT-b (s) shows a higher sensitivity than the other standard tests. An ICT-b (FP) strategy could be used as a first-step point-of-care screening tool for probable chronic schistosomiasis.</p>

PB - Oxford Academic
PY - 2025
T2 - Open Forum Infectious Diseases
TI - Performance (Sensitivity and Specificity) of a New Point-of-Care Immunochromatography to Screen for Imported Chronic Schistosomiasis Among Long-Term Sub-Saharan Migrants 
UR - https://academic.oup.com/ofid/article/12/7/ofaf328/8196494#google_vignette
VL - 12
ER -