TY - JOUR
KW - Survival Analysis
KW - Treatment
KW -  Leishmania (Viannia) braziliensis
KW - disseminated leishmaniasis
AU - Leal JFDC
AU - Bezerra Silva CC
AU - Nascimento MBS
AU - Gonçalves RT
AU - Fernandes LHG
AU - Campos ASC
AU - Araújo FMD
AU - Sampaio RNR
AU - Barroso DH
AB - <p><strong>Background/Objectives:</strong></p>

<p>American Tegumentary leishmaniasis typically presents as a single ulcerative lesion, but atypical clinical forms exist with diverse physiopathology and treatment responses. Disseminated cutaneous leishmaniasis is a less common presentation that is often challenging to treat and for which evidence-based clinical decisions are scant. A better understanding of treatment response may support the development of alternative therapeutic strategies. This study reports a retrospective cohort analysis using a time-to-event outcome to compare disseminated leishmaniasis with localized cutaneous leishmaniasis using a multivariate model.</p>

<p><strong>Methods:</strong></p>

<p>A total of 366 patients were screened for inclusion between 2014 and 2024, of whom 123 met the inclusion criteria.</p>

<p><strong>Results:</strong></p>

<p>After adjustment for age and sex, patients with disseminated cutaneous leishmaniasis had a significantly longer time to healing than those with localized cutaneous leishmaniasis (HR = 0.29; p = 0.021).</p>

<p><strong>Conclusions:</strong></p>

<p>Disseminated cutaneous leishmaniasis seems to be an important predictor of poorer clinical outcomes with prolonged healing time. New therapeutic strategies are urgently needed to address this issue.</p>

BT - Biomedicines
DA - 08/2026
DO - 10.3390/biomedicines14081762
IS - 8
LA - ENG
M3 - Article 
N2 - <p><strong>Background/Objectives:</strong></p>

<p>American Tegumentary leishmaniasis typically presents as a single ulcerative lesion, but atypical clinical forms exist with diverse physiopathology and treatment responses. Disseminated cutaneous leishmaniasis is a less common presentation that is often challenging to treat and for which evidence-based clinical decisions are scant. A better understanding of treatment response may support the development of alternative therapeutic strategies. This study reports a retrospective cohort analysis using a time-to-event outcome to compare disseminated leishmaniasis with localized cutaneous leishmaniasis using a multivariate model.</p>

<p><strong>Methods:</strong></p>

<p>A total of 366 patients were screened for inclusion between 2014 and 2024, of whom 123 met the inclusion criteria.</p>

<p><strong>Results:</strong></p>

<p>After adjustment for age and sex, patients with disseminated cutaneous leishmaniasis had a significantly longer time to healing than those with localized cutaneous leishmaniasis (HR = 0.29; p = 0.021).</p>

<p><strong>Conclusions:</strong></p>

<p>Disseminated cutaneous leishmaniasis seems to be an important predictor of poorer clinical outcomes with prolonged healing time. New therapeutic strategies are urgently needed to address this issue.</p>

PB - MDPI AG
PY - 2026
SP - 1 
EP -  9
T2 - Biomedicines
TI - Survival Analysis in Cutaneous Leishmaniasis Patients: A Retrospective Cohort Study
UR - https://www.mdpi.com/2227-9059/14/8/1762/pdf?version=1785918265
VL - 14
SN - 2227-9059
ER -