Guilherme Calvet and colleagues reported the detection and sequencing of Zika virus from amniotic fluid. The two pregnant women from the state of Paraiba in Brazil experienced a Zika-like febrile illness at weeks 18 and 10 of gestation. IgM serology and qRT-PCR for Zika virus were done in both patients in serum, urine, and amniotic fl uid samples, and reported positive for Zika virus only in amniotic fluids. Absence of a positive Zika virus serology in serum and urine is noteworthy and raises concerns in terms of proper diagnosis and clinical management of febrile syndromes in pregnant women resident in or travelling to Zika-endemic countries. No standardised diagnostic tests are commercially available for Zika virus infection and all diagnosis is based on homemade methods restricted to highly specialised virology laboratories.
BT - The Lancet. Infectious diseases C1 -http://www.ncbi.nlm.nih.gov/pubmed/27352748?dopt=Abstract
DO - 10.1016/S1473-3099(16)30074-3 IS - 7 J2 - Lancet Infect Dis LA - eng M3 - Correspondence N2 -Guilherme Calvet and colleagues reported the detection and sequencing of Zika virus from amniotic fluid. The two pregnant women from the state of Paraiba in Brazil experienced a Zika-like febrile illness at weeks 18 and 10 of gestation. IgM serology and qRT-PCR for Zika virus were done in both patients in serum, urine, and amniotic fl uid samples, and reported positive for Zika virus only in amniotic fluids. Absence of a positive Zika virus serology in serum and urine is noteworthy and raises concerns in terms of proper diagnosis and clinical management of febrile syndromes in pregnant women resident in or travelling to Zika-endemic countries. No standardised diagnostic tests are commercially available for Zika virus infection and all diagnosis is based on homemade methods restricted to highly specialised virology laboratories.
PY - 2016 SP - 771 EP - 2 T2 - The Lancet. Infectious diseases TI - Diagnosis of Zika virus infection in pregnant women travelling to or residing in endemic areas. UR - http://www.thelancet.com/pdfs/journals/laninf/PIIS1473-3099(16)30074-3.pdf VL - 16 SN - 1474-4457 ER -