Dendrotoxin, the most potent component of Mamba snake venom is considered to be majorly responsible for the exceedingly high rate of morbidity and mortality observed in Mamba snake victims. Studies suggest that in addition to inducing toxicity in the brain and other organs, the footprints of dendrotoxin can also be seen in various other neurological and physiological conditions. The understanding of dendrotoxin has been further deepened by its applications in neurophysiology. Studies have been done on the binding of dendrotoxin at various sites in the brain, therefore suggesting a pathological connection. In this review, authors highlight the involvement of dendrotoxin in diverse neurological conditions either in the induction of direct neurotoxicity or having the potential to be involved in the pathology of various neurological disorders. The authors also explain here the molecular mechanisms associated with dendrotoxin along with other components of mamba venom. Need for the search of a potent, yet safer drug candidate, which can be effective in cases of delayed medical assistance in mamba snake victims, is also urged upon.
BT - EC pharmacology and toxicology J2 - EC Pharmacol Toxicol LA - eng N2 -Dendrotoxin, the most potent component of Mamba snake venom is considered to be majorly responsible for the exceedingly high rate of morbidity and mortality observed in Mamba snake victims. Studies suggest that in addition to inducing toxicity in the brain and other organs, the footprints of dendrotoxin can also be seen in various other neurological and physiological conditions. The understanding of dendrotoxin has been further deepened by its applications in neurophysiology. Studies have been done on the binding of dendrotoxin at various sites in the brain, therefore suggesting a pathological connection. In this review, authors highlight the involvement of dendrotoxin in diverse neurological conditions either in the induction of direct neurotoxicity or having the potential to be involved in the pathology of various neurological disorders. The authors also explain here the molecular mechanisms associated with dendrotoxin along with other components of mamba venom. Need for the search of a potent, yet safer drug candidate, which can be effective in cases of delayed medical assistance in mamba snake victims, is also urged upon.
PY - 2018 SP - 469 EP - 476 T2 - EC pharmacology and toxicology TI - Neurological implications of dendrotoxin: A review. UR - https://www.ecronicon.com/ecpt/pdf/ECPT-06-00187.pdf ER -