TY - JOUR
KW - Immunology and Allergy
KW - Infectious Diseases
AU - Coffeng L
AU - Malizia V
AU - Vegvari C
AU - Cools P
AU - Halliday KE
AU - Levecke B
AU - Mekonnen Z
AU - Gichuki PM
AU - Sayasone S
AU - Sarkar R
AU - Shaali A
AU - Vlaminck J
AU - Anderson RM
AU - de Vlas S
AB - Abstract
Starting and stopping preventive chemotherapy (PC) for soil-transmitted helminthiasis is typically based on the prevalence of infection as measured by Kato-Katz (KK) fecal smears. Kato-Katz-based egg counts can vary highly over repeated stool samples and smears. Consequentially, the sensitivity of KK-based surveys depends on the number of stool samples per person and the number of smears per sample. Given finite resources, collecting multiple samples and/or smears means screening fewer individuals, thereby lowering the statistical precision of prevalence estimates. Using population-level data from various epidemiological settings, we assessed the performance of different sampling schemes executed within the confines of the same budget. We recommend the use of single-slide KK for determining prevalence of moderate-to-heavy intensity infection and policy decisions for starting and continuing PC; more sensitive sampling schemes may be required for policy decisions involving stopping PC. Our findings highlight that guidelines should include specific guidance on sampling schemes.
BT - The Journal of Infectious Diseases
DO - 10.1093/infdis/jiz535
N2 - Abstract
Starting and stopping preventive chemotherapy (PC) for soil-transmitted helminthiasis is typically based on the prevalence of infection as measured by Kato-Katz (KK) fecal smears. Kato-Katz-based egg counts can vary highly over repeated stool samples and smears. Consequentially, the sensitivity of KK-based surveys depends on the number of stool samples per person and the number of smears per sample. Given finite resources, collecting multiple samples and/or smears means screening fewer individuals, thereby lowering the statistical precision of prevalence estimates. Using population-level data from various epidemiological settings, we assessed the performance of different sampling schemes executed within the confines of the same budget. We recommend the use of single-slide KK for determining prevalence of moderate-to-heavy intensity infection and policy decisions for starting and continuing PC; more sensitive sampling schemes may be required for policy decisions involving stopping PC. Our findings highlight that guidelines should include specific guidance on sampling schemes.
PB - Oxford University Press (OUP)
PY - 2019
T2 - The Journal of Infectious Diseases
TI - Impact of Different Sampling Schemes for Decision Making in Soil-Transmitted Helminthiasis Control Programs
SN - 0022-1899, 1537-6613
ER -