Female genital schistosomiasis (FGS) results from egg-deposition in the female reproductive tract primarily by the waterborne parasite Schistosoma (S.) haematobium, and less commonly by Schistosoma (S.) mansoni. FGS affects an estimated 20-56 million women worldwide, mostly in sub-Saharan Africa. There is cross-sectional evidence of increased HIV-1 prevalence in schistosomiasis-infected women, but a causal relationship between FGS and either HIV-1 acquisition or transmission has not been fully established. Beyond the pathognomonic breach in the cervicovaginal barrier caused by FGS, this narrative review explores potential mechanisms for a synergistic relationship between S. haematobium infection, FGS, and HIV-1 acquisition through vaginal inflammation and target cell recruitment.
BT - Acta tropica C1 - https://www.ncbi.nlm.nih.gov/pubmed/32416076 DA - 05/2020 DO - 10.1016/j.actatropica.2020.105524 J2 - Acta Trop. LA - eng N2 -Female genital schistosomiasis (FGS) results from egg-deposition in the female reproductive tract primarily by the waterborne parasite Schistosoma (S.) haematobium, and less commonly by Schistosoma (S.) mansoni. FGS affects an estimated 20-56 million women worldwide, mostly in sub-Saharan Africa. There is cross-sectional evidence of increased HIV-1 prevalence in schistosomiasis-infected women, but a causal relationship between FGS and either HIV-1 acquisition or transmission has not been fully established. Beyond the pathognomonic breach in the cervicovaginal barrier caused by FGS, this narrative review explores potential mechanisms for a synergistic relationship between S. haematobium infection, FGS, and HIV-1 acquisition through vaginal inflammation and target cell recruitment.
PY - 2020 EP - 105524 T2 - Acta tropica TI - Beyond the barrier: Female Genital Schistosomiasis as a potential risk factor for HIV-1 acquisition. UR - https://reader.elsevier.com/reader/sd/pii/S0001706X19314391?token=725AE7FAB47B059FDAE841D5877717B45CB40DC28BB0259F9A85652321A5CFAB65733191CA5461F885B08FD873281C9D SN - 1873-6254 ER -