TY - JOUR
KW - Immunology and Allergy
KW - Infectious Diseases
KW - Sampling
KW - Control programmes
AU - Coffeng L
AU - Malizia V
AU - Vegvari C
AU - Cools P
AU - Halliday KE
AU - Levecke B
AU - Mekonnen Z
AU - Gichuki PM
AU - Sayasone S
AU - Sarkar R
AU - Shaali A
AU - Vlaminck J
AU - Anderson RM
AU - de Vlas S
AB - <jats:title>Abstract</jats:title>
               <jats:p>Starting and stopping preventive chemotherapy (PC) for soil-transmitted helminthiasis is typically based on the prevalence of infection as measured by Kato-Katz (KK) fecal smears. Kato-Katz-based egg counts can vary highly over repeated stool samples and smears. Consequentially, the sensitivity of KK-based surveys depends on the number of stool samples per person and the number of smears per sample. Given finite resources, collecting multiple samples and/or smears means screening fewer individuals, thereby lowering the statistical precision of prevalence estimates. Using population-level data from various epidemiological settings, we assessed the performance of different sampling schemes executed within the confines of the same budget. We recommend the use of single-slide KK for determining prevalence of moderate-to-heavy intensity infection and policy decisions for starting and continuing PC; more sensitive sampling schemes may be required for policy decisions involving stopping PC. Our findings highlight that guidelines should include specific guidance on sampling schemes.</jats:p>
BT - The Journal of Infectious Diseases
DO - 10.1093/infdis/jiz535
IS - Supplement_5
LA - eng
N2 - <jats:title>Abstract</jats:title>
               <jats:p>Starting and stopping preventive chemotherapy (PC) for soil-transmitted helminthiasis is typically based on the prevalence of infection as measured by Kato-Katz (KK) fecal smears. Kato-Katz-based egg counts can vary highly over repeated stool samples and smears. Consequentially, the sensitivity of KK-based surveys depends on the number of stool samples per person and the number of smears per sample. Given finite resources, collecting multiple samples and/or smears means screening fewer individuals, thereby lowering the statistical precision of prevalence estimates. Using population-level data from various epidemiological settings, we assessed the performance of different sampling schemes executed within the confines of the same budget. We recommend the use of single-slide KK for determining prevalence of moderate-to-heavy intensity infection and policy decisions for starting and continuing PC; more sensitive sampling schemes may be required for policy decisions involving stopping PC. Our findings highlight that guidelines should include specific guidance on sampling schemes.</jats:p>
PB - Oxford University Press (OUP)
PY - 2019
SP - S531
EP - S538
T2 - The Journal of Infectious Diseases
TI - Impact of Different Sampling Schemes for Decision Making in Soil-Transmitted Helminthiasis Control Programs
UR - https://watermark.silverchair.com/jiz535.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAqgwggKkBgkqhkiG9w0BBwagggKVMIICkQIBADCCAooGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMOkPv6vNVM9crjZUJAgEQgIICW4Z6vqzWK7GrPaF58ccd4ZHlLhOV1MWGi6EB3TE4YBk6gUil
VL - 221
SN - 0022-1899, 1537-6613
ER -