TY - JOUR KW - General Medicine KW - Vision impairment KW - Blindness AU - Adelson JD AU - Bourne RRA AU - Briant PS AU - Flaxman SR AU - Taylor HRB AU - Jonas JB AU - Abdoli AA AU - Abrha WA AU - Abualhasan A AU - Abu-Gharbieh EG AU - Adal TG AU - Afshin A AU - Ahmadieh H AU - Alemayehu W AU - Alemzadeh SAS AU - Alfaar AS AU - Alipour V AU - Androudi S AU - Arabloo J AU - Arditi AB AU - Aregawi BB AU - Arrigo A AU - Ashbaugh C AU - Ashrafi ED AU - Atnafu DD AU - Bagli EA AU - Baig AAW AU - Bärnighausen TW AU - Battaglia Parodi M AU - Beheshti MS AU - Bhagavathula AS AU - Bhardwaj N AU - Bhardwaj P AU - Bhattacharyya K AU - Bijani A AU - Bikbov M AU - Bottone M AU - Braithwaite TM AU - Bron AM AU - Burugina Nagaraja SA AU - Butt ZA AU - Caetano dos Santos FLL AU - Carneiro VLJ AU - Casson RJ AU - Cheng CJ AU - Choi JJ AU - Chu D AU - Cicinelli MVM AU - Coelho JMG AU - Congdon NGA AU - Couto RAA AU - Cromwell EAM AU - Dahlawi SM AU - Dai X AU - Dana R AU - Dandona L AU - Dandona RA AU - Del Monte MA AU - Derbew Molla M AU - Dervenis NA AU - Desta AAP AU - Deva JP AU - Diaz D AU - Djalalinia SE AU - Ehrlich JR AU - Elayedath RR AU - Elhabashy HRB AU - Ellwein LB AU - Emamian MH AU - Eskandarieh S AU - Farzadfar FG AU - Fernandes AG AU - Fischer FS AU - Friedman DSM AU - Furtado JM AU - Gaidhane S AU - Gazzard G AU - Gebremichael B AU - George R AU - Ghashghaee A AU - Gilani SA AU - Golechha M AU - Hamidi SR AU - Hammond BRR AU - Hartnett MERK AU - Hartono RK AU - Hashi AI AU - Hay SI AU - Hayat K AU - Heidari G AU - Ho HC AU - Holla R AU - Househ MJ AU - Huang JJE AU - Ibitoye SEM AU - Ilic IMD AU - Ilic MDD AU - Ingram ADN AU - Irvani SSN AU - Islam SMS AU - Itumalla R AU - Jayaram SP AU - Jha R AU - Kahloun R AU - Kalhor R AU - Kandel H AU - Kasa AS AU - Kavetskyy TA AU - Kayode GAH AU - Kempen JH AU - Khairallah M AU - Khalilov RA AU - Khan EAC AU - Khanna RC AU - Khatib MNA AU - Khoja TAE AU - Kim JE AU - Kim YJ AU - Kim GR AU - Kisa S AU - Kisa A AU - Kosen S AU - Koyanagi A AU - Kucuk Bicer B AU - Kulkarni VP AU - Kurmi OP AU - Landires IC AU - Lansingh VCL AU - Leasher JLE AU - LeGrand KE AU - Leveziel N AU - Limburg H AU - Liu X AU - Madhava Kunjathur S AU - Maleki S AU - Manafi N AU - Mansouri K AU - McAlinden CG AU - Meles GGM AU - Mersha AM AU - Michalek IMR AU - Miller TR AU - Misra S AU - Mohammad Y AU - Mohammadi SFA AU - Mohammed JAH AU - Mokdad AH AU - Moni MAA AU - Montasir AAR AU - Morse ARF AU - Mulaw GFC AU - Naderi M AU - Naderifar HS AU - Naidoo KS AU - Naimzada MD AU - Nangia V AU - Narasimha Swamy SM AU - Naveed DM AU - Negash HL AU - Nguyen HL AU - Nunez-Samudio VA AU - Ogbo FA AU - Ogundimu KT AU - Olagunju ATE AU - Onwujekwe OE AU - Otstavnov NO AU - Owolabi MO AU - Pakshir K AU - Panda-Jonas S AU - Parekh U AU - Park E AU - Pasovic M AU - Pawar S AU - Pesudovs K AU - Peto TQ AU - Pham HQ AU - Pinheiro M AU - Podder V AU - Rahimi-Movaghar V AU - Rahman MHUY AU - Ramulu PY AU - Rathi P AU - Rawaf SL AU - Rawaf DL AU - Rawal L AU - Reinig NM AU - Renzaho AM AU - Rezapour AL AU - Robin AL AU - Rossetti L AU - Sabour S AU - Safi S AU - Sahebkar A AU - Sahraian MAM AU - Samy AM AU - Sathian B AU - Saya GK AU - Saylan MA AU - Shaheen AAA AU - Shaikh MAT AU - Shen TT AU - Shibuya KS AU - Shiferaw WS AU - Shigematsu M AU - Shin JI AU - Silva JC AU - Silvester AA AU - Singh JA AU - Singhal DS AU - Sitorus RS AU - Skiadaresi EY AU - Skryabin VYA AU - Skryabina AA AU - Soheili AB AU - Sorrie MBARC AU - Sousa RARCT AU - Sreeramareddy CT AU - Stambolian DG AU - Tadesse EG AU - Tahhan NI AU - Tareque MI AU - Topouzis FX AU - Tran BX AU - Tsegaye GK AU - Tsilimbaris MK AU - Varma R AU - Virgili G AU - Vongpradith AT AU - Vu GT AU - Wang YX AU - Wang NH AU - Weldemariam AHK AU - West SKG AU - Wondmeneh TGY AU - Wong TY AU - Yaseri M AU - Yonemoto N AU - Yu CS AU - Zastrozhin MS AU - Zhang ZR AU - Zimsen SR AU - Resnikoff S AU - Vos T AB - Background
Many causes of vision impairment can be prevented or treated. With an ageing global population, the demands for eye health services are increasing. We estimated the prevalence and relative contribution of avoidable causes of blindness and vision impairment globally from 1990 to 2020. We aimed to compare the results with the World Health Assembly Global Action Plan (WHA GAP) target of a 25% global reduction from 2010 to 2019 in avoidable vision impairment, defined as cataract and undercorrected refractive error.

Methods
We did a systematic review and meta-analysis of population-based surveys of eye disease from January, 1980, to October, 2018. We fitted hierarchical models to estimate prevalence (with 95% uncertainty intervals [UIs]) of moderate and severe vision impairment (MSVI; presenting visual acuity from <6/18 to 3/60) and blindness (<3/60 or less than 10° visual field around central fixation) by cause, age, region, and year. Because of data sparsity at younger ages, our analysis focused on adults aged 50 years and older.

Findings
Global crude prevalence of avoidable vision impairment and blindness in adults aged 50 years and older did not change between 2010 and 2019 (percentage change −0·2% [95% UI −1·5 to 1·0]; 2019 prevalence 9·58 cases per 1000 people [95% IU 8·51 to 10·8], 2010 prevalence 96·0 cases per 1000 people [86·0 to 107·0]). Age-standardised prevalence of avoidable blindness decreased by −15·4% [–16·8 to −14·3], while avoidable MSVI showed no change (0·5% [–0·8 to 1·6]). However, the number of cases increased for both avoidable blindness (10·8% [8·9 to 12·4]) and MSVI (31·5% [30·0 to 33·1]). The leading global causes of blindness in those aged 50 years and older in 2020 were cataract (15·2 million cases [9% IU 12·7–18·0]), followed by glaucoma (3·6 million cases [2·8–4·4]), undercorrected refractive error (2·3 million cases [1·8–2·8]), age-related macular degeneration (1·8 million cases [1·3–2·4]), and diabetic retinopathy (0·86 million cases [0·59–1·23]). Leading causes of MSVI were undercorrected refractive error (86·1 million cases [74·2–101·0]) and cataract (78·8 million cases [67·2–91·4]).

Interpretation
Results suggest eye care services contributed to the observed reduction of age-standardised rates of avoidable blindness but not of MSVI, and that the target in an ageing global population was not reached. BT - The Lancet Global Health DO - 10.1016/s2214-109x(20)30489-7 IS - 2 LA - eng N2 - Background
Many causes of vision impairment can be prevented or treated. With an ageing global population, the demands for eye health services are increasing. We estimated the prevalence and relative contribution of avoidable causes of blindness and vision impairment globally from 1990 to 2020. We aimed to compare the results with the World Health Assembly Global Action Plan (WHA GAP) target of a 25% global reduction from 2010 to 2019 in avoidable vision impairment, defined as cataract and undercorrected refractive error.

Methods
We did a systematic review and meta-analysis of population-based surveys of eye disease from January, 1980, to October, 2018. We fitted hierarchical models to estimate prevalence (with 95% uncertainty intervals [UIs]) of moderate and severe vision impairment (MSVI; presenting visual acuity from <6/18 to 3/60) and blindness (<3/60 or less than 10° visual field around central fixation) by cause, age, region, and year. Because of data sparsity at younger ages, our analysis focused on adults aged 50 years and older.

Findings
Global crude prevalence of avoidable vision impairment and blindness in adults aged 50 years and older did not change between 2010 and 2019 (percentage change −0·2% [95% UI −1·5 to 1·0]; 2019 prevalence 9·58 cases per 1000 people [95% IU 8·51 to 10·8], 2010 prevalence 96·0 cases per 1000 people [86·0 to 107·0]). Age-standardised prevalence of avoidable blindness decreased by −15·4% [–16·8 to −14·3], while avoidable MSVI showed no change (0·5% [–0·8 to 1·6]). However, the number of cases increased for both avoidable blindness (10·8% [8·9 to 12·4]) and MSVI (31·5% [30·0 to 33·1]). The leading global causes of blindness in those aged 50 years and older in 2020 were cataract (15·2 million cases [9% IU 12·7–18·0]), followed by glaucoma (3·6 million cases [2·8–4·4]), undercorrected refractive error (2·3 million cases [1·8–2·8]), age-related macular degeneration (1·8 million cases [1·3–2·4]), and diabetic retinopathy (0·86 million cases [0·59–1·23]). Leading causes of MSVI were undercorrected refractive error (86·1 million cases [74·2–101·0]) and cataract (78·8 million cases [67·2–91·4]).

Interpretation
Results suggest eye care services contributed to the observed reduction of age-standardised rates of avoidable blindness but not of MSVI, and that the target in an ageing global population was not reached. PB - Elsevier BV PY - 2021 SP - e144 EP - e160 T2 - The Lancet Global Health TI - Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for the Global Burden of Disease Study UR - https://www.thelancet.com/action/showPdf?pii=S2214-109X%2820%2930489-7 VL - 9 SN - 2214-109X ER -