TY - JOUR
KW - Parasitology
KW - Virology
KW - Infectious Diseases
AU - Cooley GM
AU - Feldstein LR
AU - Bennett SD
AU - Estivariz CF
AU - Weil L
AU - Bohara R
AU - Vandenent M
AU - Mainul Hasan A
AU - Akhtar MS
AU - Uzzaman MS
AU - Billah MM
AU - Conklin L
AU - Ehlman DC
AU - Asiedu K
AU - Solomon AW
AU - Alamgir A
AU - Flora MS
AU - Martin DL
AB - <jats:title>Abstract.</jats:title><jats:p>Successful achievement of global targets for elimination of trachoma as a public health problem and eradication of yaws will require control efforts to reach marginalized populations, including refugees. Testing for serologic evidence of transmission of trachoma and yaws in residents of registered camps and a Makeshift Settlement in Cox’s Bazar District, Bangladesh, was added to a serosurvey for vaccine-preventable diseases (VPDs) conducted April–May 2018. The survey was primarily designed to estimate remaining immunity gaps for VPDs, including diphtheria, measles, rubella, and polio. Blood specimens from 1- to 14-year-olds from selected households were collected and tested for antibody responses against antigens from <jats:italic>Treponema pallidum</jats:italic> and <jats:italic>Chlamydia trachomatis</jats:italic> using a multiplex bead assay to evaluate for serologic evidence of the neglected tropical diseases (NTDs) yaws and trachoma, respectively. The prevalence of antibodies against two <jats:italic>C. trachomatis</jats:italic> antigens in children ranged from 1.4% to 1.5% for Pgp3 and 2.8% to 7.0% for CT694. The prevalence of antibody responses against both of two treponemal antigens (recombinant protein17 and treponemal membrane protein A) tested was 0% to 0.15% in two camps. The data are suggestive of very low or no transmission of trachoma and yaws, currently or previously, in children resident in these communities. This study illustrates how integrated serologic testing can provide needed data to help NTD programs prioritize limited resources.</jats:p>
BT - The American Journal of Tropical Medicine and Hygiene
DO - 10.4269/ajtmh.21-0124
IS - 6
LA - eng
N2 - <jats:title>Abstract.</jats:title><jats:p>Successful achievement of global targets for elimination of trachoma as a public health problem and eradication of yaws will require control efforts to reach marginalized populations, including refugees. Testing for serologic evidence of transmission of trachoma and yaws in residents of registered camps and a Makeshift Settlement in Cox’s Bazar District, Bangladesh, was added to a serosurvey for vaccine-preventable diseases (VPDs) conducted April–May 2018. The survey was primarily designed to estimate remaining immunity gaps for VPDs, including diphtheria, measles, rubella, and polio. Blood specimens from 1- to 14-year-olds from selected households were collected and tested for antibody responses against antigens from <jats:italic>Treponema pallidum</jats:italic> and <jats:italic>Chlamydia trachomatis</jats:italic> using a multiplex bead assay to evaluate for serologic evidence of the neglected tropical diseases (NTDs) yaws and trachoma, respectively. The prevalence of antibodies against two <jats:italic>C. trachomatis</jats:italic> antigens in children ranged from 1.4% to 1.5% for Pgp3 and 2.8% to 7.0% for CT694. The prevalence of antibody responses against both of two treponemal antigens (recombinant protein17 and treponemal membrane protein A) tested was 0% to 0.15% in two camps. The data are suggestive of very low or no transmission of trachoma and yaws, currently or previously, in children resident in these communities. This study illustrates how integrated serologic testing can provide needed data to help NTD programs prioritize limited resources.</jats:p>
PB - American Society of Tropical Medicine and Hygiene
PY - 2021
SP - 2031
EP - 2037
T2 - The American Journal of Tropical Medicine and Hygiene
TI - No Serological Evidence of Trachoma or Yaws Among Residents of Registered Camps and Makeshift Settlements in Cox’s Bazar, Bangladesh
UR - https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8176462&blobtype=pdf
VL - 104
SN - 0002-9637, 1476-1645
ER -