TY - JOUR
KW - Antivenom
KW - clinical practice guideline
KW - Health Education
KW - snakebite
KW - Validation
AU - Rocha G
AU - Farias A
AU - Alcântara J
AU - Machado V
AU - Murta F
AU - Val F
AU - Cristino J
AU - Santos A
AU - Ferreira M
AU - Marques L
AU - Rocha Y
AU - Sachett A
AU - Almeida M
AU - Alencar A
AU - Brasileiro L
AU - Carvalho É
AU - Bisneto P
AU - Lacerda M
AU - Tupetz A
AU - Staton C
AU - Vissoci J
AU - Teixeira E
AU - Gerardo C
AU - Wen F
AU - Sachett J
AU - Monteiro W
AB - <p>Snakebite envenoming (SBE) is a neglected tropical disease with significant global morbidity and mortality. Even when antivenom is available in low-resource areas, health workers do not receive adequate training to manage SBEs. This study aims to develop and validate a clinical practice guideline (CPG) for SBE management across Brazil. A panel of expert judges with academic and/or technical expertise in SBE management performed content validation. The content validity index (CVI) score was 90% for CPG objectives, 89% for structure and presentation and 92% for relevance and classified the CPG as valid. A semantic validation was performed by analyzing focus group discussions with doctors and nurses from three municipalities of the Brazilian Amazon, after a 5-day meeting during which the CPG was presented. Two central themes emerged: knowledge acquired during the meeting and recommendations for improving the CPG. Based on these results, the CPG was revised into a final version. This study presents the successful development and validation process of a CPG for SBE management, which is targeted to a specific low-resource, high-burden setting. This development and validation process can be adapted to other settings and/or other neglected tropical diseases.</p>

BT - Toxins
C1 - <p>https://www.ncbi.nlm.nih.gov/pubmed/35737037</p>

DA - 05/2022
DO - 10.3390/toxins14060376
IS - 6
J2 - Toxins (Basel)
LA - eng
N2 - <p>Snakebite envenoming (SBE) is a neglected tropical disease with significant global morbidity and mortality. Even when antivenom is available in low-resource areas, health workers do not receive adequate training to manage SBEs. This study aims to develop and validate a clinical practice guideline (CPG) for SBE management across Brazil. A panel of expert judges with academic and/or technical expertise in SBE management performed content validation. The content validity index (CVI) score was 90% for CPG objectives, 89% for structure and presentation and 92% for relevance and classified the CPG as valid. A semantic validation was performed by analyzing focus group discussions with doctors and nurses from three municipalities of the Brazilian Amazon, after a 5-day meeting during which the CPG was presented. Two central themes emerged: knowledge acquired during the meeting and recommendations for improving the CPG. Based on these results, the CPG was revised into a final version. This study presents the successful development and validation process of a CPG for SBE management, which is targeted to a specific low-resource, high-burden setting. This development and validation process can be adapted to other settings and/or other neglected tropical diseases.</p>

PY - 2022
T2 - Toxins
TI - Validation of a Culturally Relevant Snakebite Envenomation Clinical Practice Guideline in Brazil.
UR - https://www.mdpi.com/2072-6651/14/6/376/pdf?version=1653811110
VL - 14
SN - 2072-6651
ER -