TY - JOUR
KW - Infectious Diseases
KW - Public Health, Environmental and Occupational Health
AU - Muhi S
AU - Osowicki J
AU - O’Brien D
AU - Johnson PDR
AU - Pidot S
AU - Doerflinger M
AU - Marshall JL
AU - Pellegrini M
AU - McCarthy J
AU - Stinear TP
AU - Converse PJ
AB - <p>Critical knowledge gaps regarding infection with Mycobacterium ulcerans, the cause of Buruli ulcer (BU), have impeded development of new therapeutic approaches and vaccines for prevention of this neglected tropical disease. Here, we review the current understanding of host–pathogen interactions and correlates of immune protection to explore the case for establishing a controlled human infection model of M. ulcerans infection. We also summarise the overarching safety considerations and present a rationale for selecting a suitable challenge strain.</p>

BT - PLOS Neglected Tropical Diseases
DO - 10.1371/journal.pntd.0011394
IS - 6
LA - Eng
N2 - <p>Critical knowledge gaps regarding infection with Mycobacterium ulcerans, the cause of Buruli ulcer (BU), have impeded development of new therapeutic approaches and vaccines for prevention of this neglected tropical disease. Here, we review the current understanding of host–pathogen interactions and correlates of immune protection to explore the case for establishing a controlled human infection model of M. ulcerans infection. We also summarise the overarching safety considerations and present a rationale for selecting a suitable challenge strain.</p>

PB - Public Library of Science (PLoS)
PY - 2023
EP - e0011394
T2 - PLOS Neglected Tropical Diseases
TI - A human model of Buruli ulcer: The case for controlled human infection and considerations for selecting a Mycobacterium ulcerans challenge strain
UR - https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0011394&type=printable
VL - 17
SN - 1935-2735
ER -