02659nas a2200313   4500000000100000008004100001653001100042653001700053653001700070653000900087653001700096653001800113100001500131700001500146700001200161700001600173700001400189700001500203700001200218700001400230700001600244700001000260700001500270700001400285245007000299856003100369520193100400022001402331       2017                            d10aUganda10aRisk Factors10aPodoconiosis10aNTDs10aFoot hygiene10aElephantiasis1 aMusenero M1 aNanyunja M1 aLali WZ1 aNabukenya I1 aKihembo C1 aKaharuza F1 aArio AR1 aMasiira B1 aMatovu JK B1 aZhu B1 aMatwale GK1 aMakumbi I00aRisk factors for podoconiosis: Kamwenge District, Western Uganda.  uhttp://tinyurl.com/l9spcjd3 a<p>Podoconiosis, a noninfectious elephantiasis, is a disabling neglected tropical disease. In August 2015, an elephantiasis case-cluster was reported in Kamwenge District, western Uganda. We investigated to identify the disease's nature and risk factors. We defined a suspected podoconiosis case as onset in a Kamwenge resident of bilateral asymmetrical lower limb swelling lasting ≥ 1 month, plus ≥ 1 of the following associated symptoms: skin itching, burning sensation, plantar edema, lymph ooze, prominent skin markings, rigid toes, or mossy papillomata. A probable case was a suspected case with negative microfilaria antigen immunochromatographic card test (ruling out filarial elephantiasis). We conducted active case-finding. In a case–control investigation, we tested the hypothesis that the disease was caused by prolonged foot skin exposure to irritant soils, using 40 probable case-persons and 80 asymptomatic village control-persons, individually matched by age and sex. We collected soil samples to characterize irritants. We identified 52 suspected (including 40 probable) cases with onset from 1980 to 2015. Prevalence rates increased with age; annual incidence (by reported onset of disease) was stable over time at 2.9/100,000. We found that 93% (37/40) of cases and 68% (54/80) of controls never wore shoes at work (Mantel–Haenszel odds ratio [ORMH] = 7.7; 95% [confidence interval] CI = 2.0–30); 80% (32/40) of cases and 49% (39/80) of controls never wore shoes at home (ORMH = 5.2; 95% CI = 1.8–15); and 70% (27/39) of cases and 44% (35/79) of controls washed feet at day end (versus immediately after work) (OR = 11; 95% CI = 2.1–56). Soil samples were characterized as rich black-red volcanic clays. In conclusion, this reported elephantiasis is podoconiosis associated with prolonged foot exposure to volcanic soil. We recommended foot hygiene and universal use of protective shoes.</p>
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