03146nas a2200373   4500000000100000008004100001653001000042653001100052653002200063653001500085653000900100653002400109653001700133653001600150653001100166653001100177653001000188653001700198653000900215653001600224653001200240100001400252700001200266700001200278700001300290700001300303700001100316245005500327856009800382300001300480490000700493520225800500022001402758       2017                            d10aAdult10aAfrica10aAntifungal Agents10aAscomycota10aAsia10aChromoblastomycosis10aDrug Therapy10aCombination10aFemale10aHumans10aIndia10aItraconazole10aMale10aMiddle Aged10aMycoses1 aAgarwal R1 aSingh G1 aGhosh A1 aVerma KK1 aPandey M1 aXess I00aChromoblastomycosis in India: Review of 169 cases.  uhttp://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0005534&type=printable  ae00055340 v113 a<p>Chromoblastomycosis (CBM) is a chronic, progressive, cutaneous and subcutaneous fungal infection following the traumatic implantation of certain dematiaceous fungi. The disease has worldwide prevalence with predominant cases reported from humid tropical and subtropical regions of America, Asia, and Africa. Diagnosis is often delayed or misdirected either due to poor degree of clinical suspicions or clinical simulation of dermatological conditions. The infection is not uncommon in India and several case reports from the sub-Himalayan belt and western and eastern coasts of India have been published; however, very few have reviewed the cases. We reviewed 169 cases published in English literature from India during 1957 through May 2016, including 2 recent cases from our institute. A tremendous increase in the number of reported cases was noticed since 2012, since which, more than 50% of the cases had been published. A majority of the patients (74.1%) were involved in various agricultural activities directly or indirectly. The mean age at presentation was 43.3 years ± 16.0, with male to female ratio of 4.2:1. The duration of disease at the time of presentation varied from 20 days to 35 years. Any history of trauma was recalled only in 33.8% of the studied cases. The lower extremity was the most common site afflicted, followed by the upper extremity. The culture was positive in 80.3% of the cases with Fonsecaea pedrosoi, isolated as the most common fungal pathogen, followed by Cladophialophora carrionii. Although all the commercially available antifungals were prescribed in these cases, itraconazole and terbinafine were the most commonly used, either alone or in combination with other drugs/physical methods, with variable degrees of outcome. Combinations of different treatment modalities (chemotherapy and physical methods) yielded a cure rate of 86.3%. CBM is refractory to treatment and no single antifungal agent or regimen has demonstrated satisfactory results. Increased awareness with early clinical suspicion of the disease and adequate therapy are necessary to improve the outcome. However, depending upon the causative agent, disease severity, and the choice of antifungals, variable outcomes can be observed.</p>
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