Clinico-immunological spectrum of American tegumentary leishmaniasis and leprosy coinfection: A case series in Southeastern Brazil.

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TitleClinico-immunological spectrum of American tegumentary leishmaniasis and leprosy coinfection: A case series in Southeastern Brazil.
Publication TypeJournal Article
AuthorsVernal S, Bueno-Filho R, Gomes CM, Roselino AM
Abbrev. JournalRev. Soc. Bras. Med. Trop.
JournalRevista da Sociedade Brasileira de Medicina Tropical
Year of Publication2019
Volume52
Paginatione20180172
Publication Languageeng
Abstract

INTRODUCTION: American tegumentary leishmaniasis (ATL) and leprosy share common areas of prevalence, but reports of coinfection are scarce.

METHODS: We report a series of 9 ATL-leprosy cases and discuss the association. An integrative diagram to analyze the clinico-immunological features of coinfection with both diseases.

RESULTS: Nine patients with leishmaniasis (5 cutaneous, 3 mucocutaneous, 1 disseminated case) exhibited concurrent infection with distinct clinical forms of leprosy. Our diagram-based analysis evidenced a divergent clinico-immunological spectrum for each disease in 8 out of 9 cases.

CONCLUSIONS: The spectrum of ATL-leprosy comorbidity suggests that the host has a specific immune response against each pathogen.

PubMed URL

http://www.ncbi.nlm.nih.gov/pubmed/30994795?dopt=Abstract

DOI10.1590/0037-8682-0172-2018
Link to full texthttp://www.scielo.br/pdf/rsbmt/v52/1678-9849-rsbmt-52-e20180172.pdf