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Publication

The burden of human African trypanosomiasis.

Abstract

Human African trypanosomiasis (HAT, or sleeping sickness) is a protozoan parasitic infection caused by Trypanosoma brucei rhodesiense or Trypanosoma brucei gambiense. These are neglected tropical diseases, and T.b. rhodesiense HAT is a zoonosis. We review current knowledge on the burden of HAT in sub-Saharan Africa, with an emphasis on the disability-adjusted life year (DALY), data sources, and methodological issues relating to the use of this metric for assessing the burden of this disease. We highlight areas where data are lacking to properly quantify the impact of these diseases, mainly relating to quantifying under-reporting and disability associated with infection, and challenge the HAT research community to tackle the neglect in data gathering to enable better evidence-based assessments of burden using DALYs or other appropriate measures.

More information

Type
Journal Article
Author
Fèvre EM
Wissmann BV
Welburn SC
Lutumba P
Year of Publication
2008
Journal
PLoS neglected tropical diseases
Volume
2
Issue
12
Number of Pages
e333
Language
eng
ISSN Number
1935-2735
DOI
10.1371/journal.pntd.0000333
Alternate Journal
PLoS Negl Trop Dis
Publication Language
eng
Regional focus