Back to search
Publication

Challenges and key research questions for yaws eradication.

Abstract

Yaws is endemic in west Africa, southeast Asia, and the Pacific region. To eradicate yaws by 2020, WHO has launched a campaign of mass treatment with azithromycin. Progress has been made towards achievement of this ambitious goal, including the validation of point-of-care and molecular diagnostic tests and piloting of the strategy in several countries, including Ghana, Vanuatu, and Papua New Guinea.

Gaps in knowledge need to be addressed to allow refinement of the eradication strategy. Studies exploring determinants of the spatial distribution of yaws are needed to help with the completion of baseline mapping. The finding that Haemophilus ducreyi causes lesions similar to yaws is particularly important and further work is needed to assess the effect of azithromycin on these lesions. The integration of diagnostic tests into different stages of the eradication campaign needs investigation. Finally, studies must be done to inform the optimum mass-treatment strategy for sustainable interruption of transmission.

More information

Type
Journal Article
Author
Marks M
Mitjà O
Vestergaard LS
Pillay A
Knauf S
Chen C
Bassat Q
Martin DL
Fegan D
Taleo F
Kool J
Lukehart S
Emerson PM
Solomon AW
Ye T
Ballard RC
Mabey DC W
Asiedu KB
Year of Publication
2015
Journal
The Lancet. infectious diseases
Issue
Sept. 8
Language
eng
ISSN Number
1474-4457
DOI
10.1016/S1473-3099(15)00136-X
Alternate Journal
Lancet Infect Dis
Publication Language
eng