Primary prevention, control of NTDs and management of NTD-related disabilities relies heavily on access to safe water, sanitation, and hygiene (WASH). There are numerous NTD transmission routes that can be interrupted with improved WASH, including trachoma, schistosomiasis, soil-transmitted helminthiasis (STH) and Guinea worm. In addition, improved WASH is vital to NTD-related wound and morbidity management and disability prevention, for example in leprosy, lymphatic filariasis and Buruli ulcer. Therefore, as endorsed by the WHO roadmap for NTDs, access to safe WASH services are key for the prevention, intensified control, management and elimination of NTDs by 2020. Though, there is still a great need for operational research on the feasibility and effectiveness of pairing specific WASH interventions with specific NTDs.