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The contribution of mass drug administration to global health: past, present and future.

Abstract

Mass drug administration (MDA) is a means of delivering safe and inexpensive essential medicines based on the principles of preventive chemotherapy, where populations or sub-populations are offered treatment without individual diagnosis. High-coverage MDA in endemic areas aims to prevent and alleviate symptoms and morbidity on the one hand and can reduce transmission on the other, together improving global health. MDA is the recommended strategy of the World Health Organisation to control or eliminate several neglected tropical diseases (NTDs). More than 700 million people now receive these essential NTD medicines annually. The combined cost of integrated NTD MDA has been calculated to be in the order of $0.50 per person per year. Activities have recently been expanded due, in part, to the proposed attempt to eliminate certain NTDs in the coming two decades. More than 1.9 billion people need to receive MDA annually across several years if these targets are to be met. Such extensive coverage will require additional avenues of financial support, expanded monitoring and evaluation focusing on impact and drug efficacy, as well as new diagnostic tools and social science strategies to encourage adherence. MDA is a means to help reduce the burden of disease, and hence poverty, among the poorest sector of populations. It has already made significant improvements to global health and productivity and has the potential for further successes, particularly where incorporated into sanitation and education programmes. However logistical, financial and biological challenges remain.

More information

Type
Journal Article
Author
Webster JP
Molyneux DH
Hotez PJ
Fenwick A
Year of Publication
2014
Journal
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Volume
369
Issue
1645
Number of Pages
20130434
Language
eng
ISSN Number
1471-2970
DOI
10.1098/rstb.2013.0434
Alternate Journal
Philos. Trans. R. Soc. Lond., B, Biol. Sci.
Publication Language
eng