Lymphatic filariasis: Treatment, control and elimination.

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TitleLymphatic filariasis: Treatment, control and elimination.
Publication TypeJournal Article
AuthorsOttesen EA
Abbrev. JournalAdv. Parasitol.
JournalAdvances in parasitology
Year of Publication2006
Volume61
Pagination395-441
Publication Languageeng
KeywordsAnimals, Anthelmintics, Control, Elephantiasis, Filarial, Elimination, Endemic Diseases, Global health, Humans, Insect Vectors, Mosquito Control, National Health Programs, Public Health, Treatment
Abstract

Lymphatic filariasis (LF) is a disease not just treatable or controllable; it is a disease that can be eliminated. Indeed, LF is currently the target of a major global initiative to do just that; a few visionaries of the past 50 years did hypothesize that LF elimination was feasible. However, for most of the scientific and global health communities, the elimination of such a broadly disseminated, mosquito-borne disease has seemed highly unlikely. During the past decade, however, both the treatment strategies and the control strategies for LF have undergone profound paradigm shifts-all because of a rapid increase in knowledge and understanding of LF that derived directly from a series of remarkable achievements by the scientific and medical research communities. As a result, a public health dimension with a focus on affected populations, now supplements the earlier, predominantly patient-oriented clinical approach to LF. The early uncertainties, then the essential steps leading to this change in outlook are outlined below, followed by descriptions of the new strategy for LF elimination, the Global Programme created to attain this goal and the successes achieved to date.

PubMed URL

http://www.ncbi.nlm.nih.gov/pubmed/16735170?dopt=Abstract

DOI10.1016/S0065-308X(05)61010-X