Back to search
Publication

Neglected tropical skin diseases: their global elimination through integrated mass drug administration?

Abstract

In 2005, the concept of a combination of essential medicines—the “rapid-impact” package—was proposed to simultaneously target 7 high-prevalence neglected tropical diseases (NTDs) in sub-Saharan Africa through programs of annual mass drug administration.1 The approach relied on the observation that the major NTDs affecting the poorest people in sub-Saharan Africa, led by hookworm infection, ascariasis, schistosomiasis, trichuriasis, trachoma, lymphatic filariasis (LF), and onchocerciasis, have similarities in terms of their abilities to cause long-term disabilities and ultimately poverty by influencing worker productivity in the tropics and child development, as well as having effects on girls and women, especially during pregnancy. Moreover, these NTDs overlap geographically and therefore can be treated at roughly the same time through once-annual administration of an integrated package containing albendazole (or mebendazole), ivermectin, praziquantel, and azithromycin.1 Together, these medicines could be administered for less than US $1 annually, making this approach highly cost-effective.

More information

Type
Journal Article
Author
Hotez PJ
Velasquez RM
Wolf JE
Year of Publication
2014
Journal
JAMA dermatology
Volume
150
Issue
5
Number of Pages
481-2
Language
eng
ISSN Number
2168-6084
DOI
10.1001/jamadermatol.2013.8759
Alternate Journal
JAMA Dermatol
Publication Language
eng