New insights into leishmaniasis in the immunosuppressed.

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TitleNew insights into leishmaniasis in the immunosuppressed.
Publication TypeJournal Article
AuthorsAkuffo H, Costa C, van Griensven J, Burza S, Moreno J, Herrero M
Abbrev. JournalPLoS Negl Trop Dis
JournalPLoS neglected tropical diseases
Year of Publication2018
Volume12
Issue5
Paginatione0006375
Publication Languageeng
KeywordsImmunosuppression, Leishmaniasis, Neglected tropical diseases (NTDs), Visceral leishmaniasis (VL)
Abstract

Immunosuppression contributes significantly to the caseload of visceral leishmaniasis (VL). HIV coinfection, solid organ transplantation, malnutrition, and helminth infections are the most important immunosuppression-related factors. This review briefly describes the challenges of these associations. East Africa and the Indian subcontinent are the places where HIV imposes the highest burden in VL. In the highlands of Northern Ethiopia, migrant rural workers are at a greater risk of coinfection and malnutrition, while in India, HIV reduces the sustainability of a successful elimination programme. As shown from a longitudinal cohort in Madrid, VL is an additional threat to solid organ transplantation. The association with malnutrition is more complex since it can be both a cause and a consequence of VL. Different regimes for therapy and secondary prevention are discussed as well as the role of nutrients on the prophylaxis of VL in poverty-stricken endemic areas.

PubMed URL

http://www.ncbi.nlm.nih.gov/pubmed/29746470?dopt=Abstract

DOI10.1371/journal.pntd.0006375
Download PDFhttp://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0006375&type=printable