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Publication

Road map to the treatment of neglected tropical diseases: Nanocarriers interventions.

Abstract

Neglected tropical disease (NTD) is a set of 20 deadliest endemic diseases which shows its presence in most of the developing countries worldwide. Nearly 1 billion of the population are affected by it and suffered from poverty yearly. These diseases offer their own unique challenges and limitations towards effective prevention and treatment methods. Neglected tropical diseases are severe infections they may not kill the patient but debilitate the patient by causing severe skin deformities, disfigurement and horrible risks for several infections. Existing therapies for neglected diseases suffer from the loopholes like high degree of toxicity, side effects, low bioavailability, improper targeting and problematic application for affected populations. Progress in the field of nanotechnology in last decades suggested the intervention of nanocarriers to take over and drive the research and development to the next level by incorporating established drugs into the nanocarriers rather than discovering the newer drugs which is an expensive affair. These nanocarriers are believed to be a sure shot technique to fight infections at root level by virtue of its nanosize and ability to reach at cellular level. This article highlights the recent advances, rationale, targets and the challenges that are being faced to fight against NTDs and how the novel therapy tactics are able to contribute to its importance in prevention and treatment of NTDs.

More information

Type
Journal Article
Author
Joshi G
Quadir S
Yadav K
Year of Publication
2021
Journal
Journal of controlled release : official journal of the Controlled Release Society
Date Published
09/2021
Language
eng
ISSN Number
1873-4995
DOI
10.1016/j.jconrel.2021.09.020
Alternate Journal
J Control Release
PMID
34555491
Publication Language
eng