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Publication

Beyond the barrier: Female Genital Schistosomiasis as a potential risk factor for HIV-1 acquisition.

Abstract

Female genital schistosomiasis (FGS) results from egg-deposition in the female reproductive tract primarily by the waterborne parasite Schistosoma (S.) haematobium, and less commonly by Schistosoma (S.) mansoni. FGS affects an estimated 20-56 million women worldwide, mostly in sub-Saharan Africa. There is cross-sectional evidence of increased HIV-1 prevalence in schistosomiasis-infected women, but a causal relationship between FGS and either HIV-1 acquisition or transmission has not been fully established. Beyond the pathognomonic breach in the cervicovaginal barrier caused by FGS, this narrative review explores potential mechanisms for a synergistic relationship between S. haematobium infection, FGS, and HIV-1 acquisition through vaginal inflammation and target cell recruitment.

More information

Type
Journal Article
Author
Sturt A
Webb E
Francis S
Hayes R
Bustinduy A
Year of Publication
2020
Journal
Acta tropica
Number of Pages
105524
Date Published
05/2020
Language
eng
ISSN Number
1873-6254
DOI
10.1016/j.actatropica.2020.105524
Alternate Journal
Acta Trop.
PMID
32416076
Publication Language
eng