Loa loa microfilariae in skin snips: consequences for onchocerciasis monitoring and evaluation in L. loa endemic areas.

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TitleLoa loa microfilariae in skin snips: consequences for onchocerciasis monitoring and evaluation in L. loa endemic areas.
Publication TypeJournal Article
AuthorsNana-Djeunga HC, Fossuo-Thotchum F, Pion SD, Chesnais CB, Kubofcik J, Mackenzie CD, Klion AD, Boussinesq M, Nutman TB, Kamgno J
Abbrev. JournalClin. Infect. Dis.
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America
Year of Publication2019
Publication Languageeng
KeywordsLoa loa, Microfilariae, Monitoring and evaluation, Onchocerciasis
Abstract

The specificity of skin snips for onchocerciasis diagnosis is considered to be almost 100%. In this study, molecular methods revealed that microfilariae emerging from skin snips collected from highly microfilaremic Loa loa-infected individuals were largely misidentified as Onchocerca volvulus. This has important implications for onchocerciasis diagnostic testing in Loa-endemic areas.

PubMed URL

http://www.ncbi.nlm.nih.gov/pubmed/30861060?dopt=Abstract

DOI10.1093/cid/ciz172